Nanomedicine has made significant progress, but the vast majority of existing nanosystems have unclear structures, making it difficult to conduct structure-activity relationship research and controllable batch preparation, posing challenges for further clinical translation. Therefore, precision medicine based on precise nano systems is receiving increasing attention. We use metal organic cages with atomic level precision to construct precise nanomedicine systems. Metal organic cages are nano polyhedral structures formed by coordination assembly of metal ions or clusters with organic ligands. They have the characteristics of precise structure, diverse components and structures, ultra small size and cavities, easy modification, efficient preparation, and stable structure. They are ideal precision nanomedicine systems and have been widely used in biological imaging, sensing, anti-cancer, anti-inflammatory, antibacterial and other research.
