Members

Dr. Bai Xue

Email: bxue79@sjtu.edu.cn
Address: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China

Educational Background

• 1997-2001: Bachelor’s Degree, Department of Biological Science and Technology, Nanjing University

• 2001-2004: Master’s Degree, Department of Biological Science and Technology, Nanjing University

• 2005-2010: Ph.D., Department of Biological Sciences, State University of New York at Buffalo

Professional Experience

• 2010-2012: Research Assistant, Institute of Clinical Pharmacodynamics, USA

• 2013-2016: Postdoctoral Fellow, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University

• 2017-Present: Assistant Researcher, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University

Research Interests

1. Molecular biology of diseases such as diabetes and cancer, including disease progression, outcomes, and the development of disease models and related drug discovery.

2. Pharmacokinetics/pharmacodynamics (PK/PD) research and the development of related models.

3. Systems biology, bioinformatics, and translational biology.

Research Projects

• Participated in the Major National Science and Technology Projects for Major New Drug Innovation.

Selected Publications

1. Shi L, Xu L, Wu C, Xue B, et al. “Celecoxib-Induced Self-Assembly of Smart Albumin-Doxorubicin Conjugate for Enhanced Cancer Therapy”. ACS Appl Mater Interfaces, 2018, 10(10):8555-8565.

2. Xu L, Yang J, Xue B, et al. “Molecular insights for the biological interactions between polyethylene glycol and cells”. Biomaterials, 2017, 147:1-13.

3. Mou Q, Ma Y, Pan G, Xue B, et al. “DNA Trojan Horses: Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy”. Angew Chem Int Ed Engl, 2017, 56(41):12528-12532.

4. Guo D, Xu S, Wang N, Xue B, et al. “Prodrug-embedded angiogenic vessel-targeting nanoparticle: A positive feedback amplifier in hypoxia-induced chemo-photo therapy”. Biomaterials, 2017, 144:188-198.

5. Xue B, Nie J, Wang X, DuBois DC, Jusko WJ, Almon RR. “Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats”. Gene Regul Syst Bio, 2015, 9:15-26.

6. Nie J, DuBois DC, Xue B, et al. “Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats”. Gene Regul Syst Bio, 2017, 11.

7. Xue B, Zhang C, Wang Y, et al. “A Novel Controlled-Release System for Antibacterial Enzyme Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement”. PLoS One, 2014, 9(12).

8. Rubino CM, Xue B, et al. “Population Pharmacokinetic Analyses for BC-3781 Using Phase 2 Data from Patients with Acute Bacterial Skin and Skin Structure Infections”. Antimicrob Agents Chemother, 2014.

9. Xue B, Sukumaran S, et al. “Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats”. PLoS One, 2011, 6(2).

10. Almon RR, DuBois DC, Lai W, Xue B, et al. “Gene Expression Analysis of Hepatic Roles in Cause and Development of Diabetes in Goto-Kakizaki Rats”. J Endocrinol, 2009, 200(3):331-46.