Prof. Wang Dali
tenure-track Associate Professor
Email: energywang@sjtu.edu.cn
Address: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China
Educational Background
· Sep. 2005 - Jul. 2009: Bachelor’s Degree, Donghua University, supervisor: Prof. Yimin Wang
· Sep. 2009 - Feb. 2016: Ph.D., Shanghai Jiao Tong University, supervisor: Prof. Xinyuan Zhu
Professional Experience
· Mar. 2016 - Sep. 2019: Postdoctoral Fellow, Northeastern University, advisor: Prof. Ke Zhang
· Oct. 2019 - Oct. 2022: Postdoctoral Fellow, Harvard Medical School/Massachusetts Institute of Technology, advisors: Prof. Christopher Weldon, Prof. Daniel S. Kohane, Prof. Robert S. Langer
· Nov. 2022 - Present: tenure-track Associate Professor, Shanghai Jiao Tong University
Research Interests
The research group focuses on biomedical polymer materials. With clinical needs as the main driver, we work on molecular design, material synthesis, and biological performance evaluation to develop new drugs, drug delivery systems, and medical devices for fields such as cancer, genetic diseases, and neurological disorders. The main research areas include:
· Synthesis of biomedical polymer materials
· Design, delivery, and application of nucleic acid drugs (e.g., antisense DNA, siRNA, aptamers)
· Nucleic acid vaccines and immunotherapy
· Development of novel drug delivery systems and intelligent medical devices
Selected Publications
1. Wang, D.; Li, Y.; Deng, X.; Torre, M.; Zhang, Z.; Li, X.; Zhang, W.; Cullion, K.; Kohane, D. S.*; Weldon, C. B.*, An aptamer-based depot system for sustained release of small molecule therapeutics. Nat. Commun. 2023, 14, 2444.
2. Wang, D.; Wang, Q.; Wang, Y.; Chen, P.; Lu X.; Jia, F.; Sun, Y.; Sun, T.; Zhang, L.; Che, F.; He, J.; Lian, L.; Morano, G.; Shen, M.; Ren, M.; Dong, S.; Zhao, J.*; Zhang, K.*, Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2113180119.
3. Xu, L.; Yu, C.; Wang, D. *; Pang, J.; Shi, L.; Su, Y.; Gong, L.; Yan, D.; Zhu, X.*, Endogenous nucleotide as drug carrier: base-paired guanosine-5’-monophosphate: pemetrexed vesicles with enhanced anticancer capability. Sci. China Chem. 2020, 63, 244-253.
4. Wang, D.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J.; Nyoni, Z.; Lu, X.*; Zhang, K.*, Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo. Sci. Adv. 2019, 5, eaav9322. (Highlighted in Northeastern News and Science Trends)
5. Wang, D.; Yu, C.; Xu, L.; Shi, L.; Tong, G.; Wu, J.; Liu, H.; Yan, D.; Zhu, X.*, Nucleoside analogue based supramolecular nanodrugs driven by molecular recognition for synergistic cancer therapy. J. Am. Chem. Soc. 2018, 140, 8797-8806. (Top 15 Biochemistry Discoveries in 2018)
6. Wang, D.; Liu, B.; Ma, Y.; Wu, C.; Mou, Q.; Deng, H.; Wang, R.; Yan, D.; Zhang, C.*; Zhu, X.*, A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy. J. Am. Chem. Soc. 2017, 139, 14021-14024. (Highlighted in Oligonucleotide Therapeutics Society)
7. Wang, D.; Lu, X.; Jia, F.; Tan, X.; Sun, X.; Cao, X.; Wai, F.; Zhang, C.*; Zhang, K.*, Precision tuning of DNA-and poly (ethylene glycol)-based nanoparticles via coassembly for effective antisense gene regulation. Chem. Mater. 2017, 29, 9882-9886.
8. Wang, D.; Jin, Y.; Zhu, X.*; Yan, D.*, Synthesis and applications of stimuli-responsive hyperbranched polymers. Prog. Polym. Sci. 2017, 64, 114-153. (ESI Highly Cited Paper)
9. Wang, D.; Tu, C.; Su, Y.; Zhang, C.; Greiser, U.; Zhu, X.*; Yan, D.; Wang, W.*, Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery. Chem. Sci. 2015, 6, 3775-3787. (Highlighted in Chemistry World)
10. Wang, D.; Zhao, T.; Zhu, X.*; Yan, D.; Wang, W.*, Bioapplications of hyperbranched polymers. Chem. Soc. Rev. 2015, 44, 4023-4071. (ESI Highly Cited Paper)
Patents
Ke Zhang, Dali Wang. "Carrier-free, dual-adjuvanted cancer vaccine based on self-assembled DNA amphiphiles." US Application No. 63/290,797.
Ke Zhang, Dali Wang. "Poly (ethylene glycol) brushes for efficient RNA delivery." US Application No. 62/646,542.
Ke Zhang, Dali Wang. "Amphiphilic polymer micelles and use thereof." US Pub. No. US 2018/0369142 A1.
Xinyuan Zhu, Deyue Yan, Dali Wang. "Amphiphilic base-conjugated nanoparticles for tumor therapy and their preparation method," Patent No. ZL201610015514.3; Issued on August 31, 2018.
Dali Wang, Xinyuan Zhu. "Supramolecular phospholipids based on nucleic acid bases and their preparation method and liposomes," Patent No. ZL201310349981.6; Issued on June 1, 2016.
Honors and Awards
2021: National Excellent Young Scientists Fund (Overseas)
2019: Best Poster Award, Gordon Research Conference, USA
2016: Shanghai Outstanding Ph.D. Graduate
