Prof. Chuan ZHANG
Tel: 021-54740717
Email: chuanzhang@sjtu.edu.cn
Address: School of Chemistry and Chemical Engineering, 800 Dongchuan Road, Shanghai
Education
2006-2011, Analytical & Materials Chemistry, Purdue University, USA, Ph.D.
2003-2006, Analytical Chemistry, Tsinghua University, China,M.S.
1999-2003, Chemistry, Tsinghua University, China,B.S.
Working Experience
2011-2014, Postdoctoral Associate, Northwestern University, USA
2014-present, Assistant Professor, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, China
Research Interests
1) New nucleic acid drugs, gene delivery, and therapy
2) Drug delivery systems, synthesis and application of novel biomaterials
3) Nucleic acid nanotechnology, biomacromolecule functional materials, and nanobiomedicine
Research Project
1. National Natural Science Foundation of China Outstanding Young Scientist Fund, "Nucleic Acid Drug Delivery System", 2023/01-2027/12, host.
2. General Project of National Natural Science Foundation of China, "Synthesis, Assembly and Application Research of Thiooligonucleotide Drug Conjugates", 2020/01-2023/12, Chair.
3. International (Regional) Cooperation and Exchange Project of National Natural Science Foundation of China (China Hong Kong Cooperation Fund), "Construction of Highly Efficient Gene Carriers for Self Assembled DNA Nanostructures and Their Interaction with Cells", 2017/01-2020/12, Hosted.
4. General Project of National Natural Science Foundation of China, "Assembly and Performance Research of DNA Induced New Nanoparticle Superlattice Materials", 2017/01-2020/12, Chair.
5. National Key Research and Development Program Project, "Research and Application of New Polymer Ophthalmic Functional Implant Materials" Project 2, "Research and Mechanism of Orbital Soft Tissue Regeneration Materials" 2018/09-2022/06, project leader.
6. National Key Research and Development Program Project, "Design and Synthesis of Precise Self Assembly Nano Storage Elements" Project 1 "Research and Development of Data Storage Technology Using Synthetic DNA", July 2019 to June 2024, participated.
7. Major Research Program of National Natural Science Foundation of China, "Modular Assembly, Functional Integration, and Biomimetic Applications of Primary Assemblers", January 2016 December 2018, participated.
8. National Natural Science Foundation of China Youth Fund, "Research on High Density Nucleic Acid Polyester Micellar Affinity Hybrid Delivery of Gene Drugs", 2016/01-2018/12, Chair.
Selected Publications
At SJTU (Selected)
13) Yuanyuan Guo, Qiushuang Zhang, Qiwen Zhu, Jing Gao, Xinyuan Zhu, Haijun Yu,* Yuehua Li,* Chuan Zhang*, “Co-packaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy”, Sci. Adv., 2022, 8, eabn2941.
12) Lijuan Zhu, Jiapei Yang, Yuan Ma, Xinyuan Zhu, Chuan Zhang*, “Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy”, J. Am. Chem. Soc., 2022, 144, 1493-1497.
11) Yuhe Liu, Jiao Zhang, Yuanyuan Guo, Ping Wang, Yue Su, Xin Jin, Xinyuan Zhu, Chuan Zhang*, “Drug-Grafted DNA as A Novel Chemogene for Targeted Combinatorial Cancer Therapy”, Exploration, 2022, 2, 20210172.
10) Xihui Gao, Sha Li, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Virus-Mimicking Nucleic Acid Nanogel Reprograms the Microglia and Macrophage for Glioblastoma Therapy”, Adv. Mater., 2021, 33, 2006116.
9) Lijuan Zhu, Yuanyuan Guo, Qiuhui Qian, Deyue Yan, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer”, Angew. Chem. Int. Ed., 2020, 59, 17944-17950.
8) Huan Ge, Dongya Wang, Yue Pan, Yuanyuan Guo, Hongyu Li, Fan Zhang, Xinyuan Zhu, Yuehua Li, Chuan Zhang*, Ling Huang*, “Sequence-Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies”, Angew. Chem. Int. Ed., 2020, 59, 8133-8137.
7) Jiao Zhang, Yuanyuan Guo, Fei Ding, Gaifang Pan, Xinyuan Zhu, and Chuan Zhang*, “A Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth”, Angew. Chem. Int. Ed., 2019, 58, 13794-13798.
6) Xihui Gao, Sha Li, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Rapid Detection of Exosomal microRNAs Using Virus-Mimicking Fusogenic Vesicles”, Angew. Chem. Int. Ed., 2019, 58, 8719-8723.
5) Quanbing Mou, Yuan Ma, Fei Ding, Xihui Gao, Deyue Yan, Xinyuan Zhu, and Chuan Zhang*, “Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides to Reverse Chemoresistance”, J. Am. Chem. Soc., 2019, 141, 6955-6966.
4) Yuanyuan Guo, Jiao Zhang, Fei Ding, Gaifang Pan, Jing Li, Jing Feng, Xinyuan Zhu, and Chuan Zhang*, “Stressing the Role of DNA as Drug Carrier: Synthesis of the DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides”, Advanced Materials, 2019, 31, 1807533.
3) Ding F., Mou Q., Ma Y., Pan G., Guo Y., Tong G., Choi C. H. J., Zhu X., Zhang C.*, “Crosslinked Nucleic Acid Nanogel For Effective siRNA Delivery and Antitumor Therapy”, Angew. Chem. Int. Ed., 2018, 57, 3064-3068.
2) Mou Q., Ma Y., Pan G., Xue B., Yan D., Zhang C.*, Zhu X.*, “DNA Trojan Horses: The Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy”, Angew. Chem. Int. Ed., 2017, 56, 12528–12532.
1) Wang D., Liu B., Ma Y., Wu C., Mou Q., Deng H., Wang R., Yan D., Zhang C.*, Zhu X.*, “A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy”, J. Am. Chem. Soc., 2017, 139, 14021-14024.
Before SJTU (Selected)
1) Zhang C., Li X., Tian C., Li. Y., Jiang W., Mao C.D.*, “DNA Nanocages Swallow Gold Nanoparticles (AuNPs) to Form AuNP@DNA Cage Core-Shell Structures”, ACS Nano 8, 1130-1135 (2014).
2) Zhang C., Macfarlane R. J., Young K. L., Choi C. H. J., Hao L., Auyeung E., Liu G., Zhou X., Mirkin C. A.,* “A General Approach to DNA-Programmable Atom Equivalents”, Nat. Mater., 12, 741-746 (2013).
Also see: Simon U. “Nanoparticle self-assembly: Bonding them all”. Nat. Mater. 12, 694 (2013).Highlighted by C&EN, 21, 41 (2013).
3) Zhang C., Tian C., Li X., Qian H., Hao C., Wang G., Jiang W., Mao C.D.*, “Reversibly Switching the Surface Porosity of a DNA Tetrahedron”, J. Am. Chem. Soc., 134, 11998-12001 (2012).
4) Zhang C., Wu W.M., Li X., Tian C., Qian H., Wang G., Jiang W., Mao C.D.*, “Controlling the Chirality of DNA Nanocages”, Angew. Chem. Int. Ed., 51, 7999-8002 (2012).
5) Zhang C., Tian C., Guo F., Liu Z., Jiang W., Mao C.D.*, “DNA-Directed Three Dimensional (3D) Protein Organization”, Angew. Chem. Int. Ed., 51, 3382-3385 (2012).
6) Zhang C., He Y., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D.*, “Exterior modification of a DNA tetrahedron”, Chem Comm., 46, 6792-6794 (2010).
7) Zhang C., Ko S. H., Su M., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D.*, “Symmetry Controls the Face Geometry of DNA Polyhedra”, J. Am. Chem. Soc., 131: 1413-1415 (2009).
8) Zhang C., He Y., Mao C.D.*, “A Brief Review: DNA Nanocages Self-assembled by Star-shaped DNA Motifs”, Faraday Discuss., 143, 221-233 (2009).
9) Zhang C., Mao C.D.*, “DNA Nanotechnology: Bacteria as factories”, Nat. Nanotech., 3: 707-708 (2008).
10) Zhang C., Su M., He Y., Zhao X., Fang P.A., Ribbe A.E., Jiang W., Mao C.D.*; “Conformational Flexibility Facilitates Self-Assembly of Complex DNA Nanostructures”, Proc. Natl. Acad. Sci. USA, 105: 10665-10669 (2008).
11) He Y., Ye T., Su M., Zhang C., Ribbe A.E., Jiang W., Mao C.D.*, “Hierarchical Self-assembly of DNA into Symmetric SupramolecularPolyhedra”, Nature, 452: 198-201 (2008).
12) Zhang C., He Y., Chen Y., Ribbe A.E., Mao C.D.*; “Aligning One-dimensional DNA Duplexes into Two-dimensional Crystals” J. Am. Chem. Soc., 129: 14134-14135 (2007).
13) Zhang C., Zhu Y.F.*, “Synthesis of Square Bi2WO6Nanoplates as High Activity Visible-Light-Driven Photocatalysts”, Chem. Mater., 17: 3537-3545 (2005).
14) Zhang C., Wang L., Cui L.P., Zhu Y.F.*, “A Novel Method for The Synthesis of Nano-sized BaAl2O4 with Thermal Stability”, J. Cryst. Growth., 255: 317-323 (2003).
Academic Positions
2019 – present: Young Editorial Board Member of Journal of Advanced Chemistry
2018 – present: Member of the Nanobiotechnology Branch Committee of the China Medical Biotechnology Association
2018 – present: Member of the Dry Eye Prevention and Treatment Expert Committee of the China Medical and Health Development Foundation
Honors and Awards
1） 2014 "Seeking Truth Young Scholar" Award (2014“求是青年学者”奖)
2） M.G. Mellon Award （2010）
3） Bisland Fellowship (2009)
